Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices

Salvatore Pernagallo, Olga Tura, Mei Wu, Kay Samuel, Juan J. Diaz-Mochon, Anna Hansen, Rong Zhang, Melany Jackson, Gareth J. Padfield, Patrick W. F. Hadoke, Nicholas L. Mills, Marc L. Turner, John P. Iredale, David C. Hay, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.
Original languageEnglish
Pages (from-to)646-656
Number of pages11
JournalAdvanced Healthcare Materials
Volume1
Issue number5
DOIs
Publication statusPublished - Sep 2012

Keywords

  • MICROARRAYS
  • PROSTHESES
  • PROGENITOR CELLS
  • GRAFTS
  • ENDOTHELIUM

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