Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices

Salvatore Pernagallo; Olga Tura; Mei Wu; Kay Samuel; Juan J. Diaz-Mochon; Anna Hansen; Rong Zhang; Melany Jackson; Gareth J. Padfield; Patrick W. F. Hadoke; Nicholas L. Mills; Marc L. Turner; John P. Iredale; David C. Hay; Mark Bradley

doi:10.1002/adhm.201200130

Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices

Salvatore Pernagallo, Olga Tura, Mei Wu, Kay Samuel, Juan J. Diaz-Mochon, Anna Hansen, Rong Zhang, Melany Jackson, Gareth J. Padfield, Patrick W. F. Hadoke, Nicholas L. Mills, Marc L. Turner, John P. Iredale, David C. Hay^*, Mark Bradley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.

Original language	English
Pages (from-to)	646-656
Number of pages	11
Journal	Advanced Healthcare Materials
Volume	1
Issue number	5
DOIs	https://doi.org/10.1002/adhm.201200130
Publication status	Published - Sep 2012

Keywords

MICROARRAYS
PROSTHESES
PROGENITOR CELLS
GRAFTS
ENDOTHELIUM

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10.1002/adhm.201200130

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Pernagallo, S., Tura, O., Wu, M., Samuel, K., Diaz-Mochon, J. J., Hansen, A., Zhang, R., Jackson, M., Padfield, G. J., Hadoke, P. W. F., Mills, N. L., Turner, M. L., Iredale, J. P., Hay, D. C., & Bradley, M. (2012). Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices. Advanced Healthcare Materials, 1(5), 646-656. https://doi.org/10.1002/adhm.201200130

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title = "Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices",

abstract = " Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment. ",

keywords = "MICROARRAYS, PROSTHESES, PROGENITOR CELLS, GRAFTS, ENDOTHELIUM",

author = "Salvatore Pernagallo and Olga Tura and Mei Wu and Kay Samuel and Diaz-Mochon, {Juan J.} and Anna Hansen and Rong Zhang and Melany Jackson and Padfield, {Gareth J.} and Hadoke, {Patrick W. F.} and Mills, {Nicholas L.} and Turner, {Marc L.} and Iredale, {John P.} and Hay, {David C.} and Mark Bradley",

year = "2012",

month = sep,

doi = "10.1002/adhm.201200130",

language = "English",

volume = "1",

pages = "646--656",

journal = "Advanced Healthcare Materials",

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T1 - Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices

AU - Pernagallo, Salvatore

AU - Tura, Olga

AU - Wu, Mei

AU - Samuel, Kay

AU - Diaz-Mochon, Juan J.

AU - Hansen, Anna

AU - Zhang, Rong

AU - Jackson, Melany

AU - Padfield, Gareth J.

AU - Hadoke, Patrick W. F.

AU - Mills, Nicholas L.

AU - Turner, Marc L.

AU - Iredale, John P.

AU - Hay, David C.

AU - Bradley, Mark

PY - 2012/9

Y1 - 2012/9

N2 - Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.

AB - Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.

KW - MICROARRAYS

KW - PROSTHESES

KW - PROGENITOR CELLS

KW - GRAFTS

KW - ENDOTHELIUM

U2 - 10.1002/adhm.201200130

DO - 10.1002/adhm.201200130

M3 - Article

VL - 1

SP - 646

EP - 656

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

SN - 2192-2640

IS - 5

ER -

Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices

Abstract

Keywords

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