Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health

Jing Yang, Chunge Zhang, Yue Yuan, Ju Sun, Lu Lu, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, Yuhai Bi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks to poultry and to public health.

Original languageEnglish
Pages (from-to)1244-1249
JournalEmerging Infectious Diseases
Volume29
Issue number6
Early online date12 May 2023
DOIs
Publication statusPublished - Jun 2023

Keywords / Materials (for Non-textual outputs)

  • highly pathogenic avian influenza virus
  • H5N1
  • reassortant
  • genetic origin
  • phylogeography
  • antigenic variation
  • migratory bird

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