Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health

Jing Yang; Chunge Zhang; Yue  Yuan; Ju Sun; Lu Lu; Honglei Sun; Heting  Sun; Dong  Chu; Siyuan  Qin; Jianjun Chen; Chengbo  Zhang; Xiyan  Hao; Weifeng Shi; Wenjun Liu; George F. Gao; Paul Digard; Samantha Lycett; Yuhai Bi

doi:10.3201/eid2906.221723

Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health

Jing Yang, Chunge Zhang, Yue Yuan, Ju Sun, Lu Lu, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, Yuhai Bi^*

^*Corresponding author for this work

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks to poultry and to public health.

Original language	English
Pages (from-to)	1244-1249
Journal	Emerging Infectious Diseases
Volume	29
Issue number	6
Early online date	12 May 2023
DOIs	https://doi.org/10.3201/eid2906.221723
Publication status	Published - Jun 2023

Keywords / Materials (for Non-textual outputs)

highly pathogenic avian influenza virus
H5N1
reassortant
genetic origin
phylogeography
antigenic variation
migratory bird

Access to Document

10.3201/eid2906.221723

22-1723Final published version, 3.33 MBLicence: Creative Commons: Attribution (CC-BY)

Epidemiology and Modelling
Wilson, A. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research
Pathogen diversity and the basis of host-adaption and virulence
Wilson, A. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research
Predictive phylogenetics for evolutionary and transmission dynamics of newly emerging avian influenza viruses
Digard, P. (Principal Investigator), Boden, L. (Co-investigator), Lycett, S. (Co-investigator), Smith, J. (Co-investigator), Vervelde, L. (Co-investigator) & Lu, L. (Researcher)
Biotechnology and Biological Sciences Research Council
1/04/21 → 31/03/26
Project: Research

Cite this

Yang, J., Zhang, C., Yuan, Y., Sun, J., Lu, L., Sun, H., Sun, H., Chu, D., Qin, S., Chen, J., Zhang, C., Hao, X., Shi, W., Liu, W., Gao, G. F., Digard, P., Lycett, S., & Bi, Y. (2023). Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health. Emerging Infectious Diseases, 29(6), 1244-1249. https://doi.org/10.3201/eid2906.221723

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title = "Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health",

abstract = "Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks to poultry and to public health.",

keywords = "highly pathogenic avian influenza virus, H5N1, reassortant, genetic origin, phylogeography, antigenic variation, migratory bird",

author = "Jing Yang and Chunge Zhang and Yue Yuan and Ju Sun and Lu Lu and Honglei Sun and Heting Sun and Dong Chu and Siyuan Qin and Jianjun Chen and Chengbo Zhang and Xiyan Hao and Weifeng Shi and Wenjun Liu and Gao, \{George F.\} and Paul Digard and Samantha Lycett and Yuhai Bi",

year = "2023",

month = jun,

doi = "10.3201/eid2906.221723",

language = "English",

volume = "29",

pages = "1244--1249",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

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Yang, J, Zhang, C, Yuan, Y, Sun, J, Lu, L, Sun, H, Sun, H, Chu, D, Qin, S, Chen, J, Zhang, C, Hao, X, Shi, W, Liu, W, Gao, GF, Digard, P , Lycett, S & Bi, Y 2023, 'Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health', Emerging Infectious Diseases, vol. 29, no. 6, pp. 1244-1249. https://doi.org/10.3201/eid2906.221723

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AU - Yang, Jing

AU - Zhang, Chunge

AU - Yuan, Yue

AU - Sun, Ju

AU - Lu, Lu

AU - Sun, Honglei

AU - Sun, Heting

AU - Chu, Dong

AU - Qin, Siyuan

AU - Chen, Jianjun

AU - Zhang, Chengbo

AU - Hao, Xiyan

AU - Shi, Weifeng

AU - Liu, Wenjun

AU - Gao, George F.

AU - Digard, Paul

AU - Lycett, Samantha

AU - Bi, Yuhai

PY - 2023/6

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AB - Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks to poultry and to public health.

KW - highly pathogenic avian influenza virus

KW - H5N1

KW - reassortant

KW - genetic origin

KW - phylogeography

KW - antigenic variation

KW - migratory bird

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DO - 10.3201/eid2906.221723

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C2 - 37209677

SN - 1080-6040

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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ER -

Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Epidemiology and Modelling

Pathogen diversity and the basis of host-adaption and virulence

Predictive phylogenetics for evolutionary and transmission dynamics of newly emerging avian influenza viruses

Cite this