Novel lines of Pax6-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability

Jane C Quinn, Michael Molinek, Tomasz J Nowakowski, John O Mason, David J Price

Research output: Contribution to journalArticlepeer-review

Abstract

Embryonic stem (ES) cells can differentiate into all cell types and have been used extensively to study factors affecting neuronal differentiation. ES cells containing mutations in known genes have the potential to provide useful in vitro models for the study of gene function during neuronal differentiation. Recently, mouse ES cell lines lacking the neurogenic transcription factor Pax6 were reported; neurons derived from these Pax6-/- ES cells died rapidly after neuronal differentiation in vitro.
Original languageEnglish
Article number26
Number of pages10
JournalBMC Neuroscience
Volume11
DOIs
Publication statusPublished - Feb 2010

Fingerprint Dive into the research topics of 'Novel lines of Pax6-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability'. Together they form a unique fingerprint.

Cite this