Novel methods for quantifying individual host response to infectious pathogens for genetic analyses

Andrea B Doeschl-Wilson, Stephen Bishop, Ilias Kyriazakis, Beatriz Villanueva

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Here we propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance – the change in performance with respect to changes in pathogen burden in a host population – to the level of individuals. The second approach aims to capturethe dynamic aspects of individual resistance and tolerance over the entire time course of infections. In contrast to the first approach, which provides a means to disentangle host resistance from tolerance, the second approach considers the combined effects of host resistance and tolerance. Both approaches provide new individual phenotypes for subsequent genetic analyses and come with specific data requirements. Consideration of individual tolerance also highlights some of the assumptions hidden within the concept of group tolerance, indicating where care needs to be taken in trait definition and measurement.
Original languageEnglish
Article number266
JournalFrontiers in Genetics
Volume3
Issue numberOctober
DOIs
Publication statusPublished - 2012

Fingerprint

Dive into the research topics of 'Novel methods for quantifying individual host response to infectious pathogens for genetic analyses'. Together they form a unique fingerprint.

Cite this