Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran; Severine A Ouvry Patat; John B Carlin; Keith Grimwood; Alun Jones; David S Armstrong; John C Galati; Peter J Cooper; Catherine A Byrnes; Paul W Francis; Colin F Robertson; David A Hume; Christoph H Borchers; Claire E Wainwright; Brandon J Wainwright

doi:10.1373/clinchem.2007.087650

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran, Severine A Ouvry Patat, John B Carlin, Keith Grimwood, Alun Jones, David S Armstrong, John C Galati, Peter J Cooper, Catherine A Byrnes, Paul W Francis, Colin F Robertson, David A Hume, Christoph H Borchers, Claire E Wainwright, Brandon J Wainwright

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.

Original language	English
Pages (from-to)	1782-91
Number of pages	10
Journal	Clinical Chemistry
Volume	53
Issue number	10
DOIs	https://doi.org/10.1373/clinchem.2007.087650
Publication status	Published - 2007

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McMorran, B. J., Patat, S. A. O., Carlin, J. B., Grimwood, K., Jones, A., Armstrong, D. S., Galati, J. C., Cooper, P. J., Byrnes, C. A., Francis, P. W., Robertson, C. F., Hume, D. A., Borchers, C. H., Wainwright, C. E., & Wainwright, B. J. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53(10), 1782-91. https://doi.org/10.1373/clinchem.2007.087650

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title = "Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients",

abstract = "Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.",

author = "McMorran, {Brendan J} and Patat, {Severine A Ouvry} and Carlin, {John B} and Keith Grimwood and Alun Jones and Armstrong, {David S} and Galati, {John C} and Cooper, {Peter J} and Byrnes, {Catherine A} and Francis, {Paul W} and Robertson, {Colin F} and Hume, {David A} and Borchers, {Christoph H} and Wainwright, {Claire E} and Wainwright, {Brandon J}",

year = "2007",

doi = "10.1373/clinchem.2007.087650",

language = "English",

volume = "53",

pages = "1782--91",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "American Association for Clinical Chemistry Inc.",

number = "10",

}

McMorran, BJ, Patat, SAO, Carlin, JB, Grimwood, K, Jones, A, Armstrong, DS, Galati, JC, Cooper, PJ, Byrnes, CA, Francis, PW, Robertson, CF, Hume, DA, Borchers, CH, Wainwright, CE & Wainwright, BJ 2007, 'Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients', Clinical Chemistry, vol. 53, no. 10, pp. 1782-91. https://doi.org/10.1373/clinchem.2007.087650

TY - JOUR

T1 - Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

AU - McMorran, Brendan J

AU - Patat, Severine A Ouvry

AU - Carlin, John B

AU - Grimwood, Keith

AU - Jones, Alun

AU - Armstrong, David S

AU - Galati, John C

AU - Cooper, Peter J

AU - Byrnes, Catherine A

AU - Francis, Paul W

AU - Robertson, Colin F

AU - Hume, David A

AU - Borchers, Christoph H

AU - Wainwright, Claire E

AU - Wainwright, Brandon J

PY - 2007

Y1 - 2007

N2 - Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.

AB - Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.

U2 - 10.1373/clinchem.2007.087650

DO - 10.1373/clinchem.2007.087650

M3 - Article

C2 - 17702859

SN - 0009-9147

VL - 53

SP - 1782

EP - 1791

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 10

ER -

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Abstract

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