Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran, Severine A Ouvry Patat, John B Carlin, Keith Grimwood, Alun Jones, David S Armstrong, John C Galati, Peter J Cooper, Catherine A Byrnes, Paul W Francis, Colin F Robertson, David A Hume, Christoph H Borchers, Claire E Wainwright, Brandon J Wainwright

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.
Original languageEnglish
Pages (from-to)1782-91
Number of pages10
JournalClinical Chemistry
Volume53
Issue number10
DOIs
Publication statusPublished - 2007

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