Projects per year
Abstract / Description of output
Resolution of inflammation requires the effective downregulation of key inflammatory cells such as neutrophils and eosinophils, which normally undergo programmed cell death (apoptosis) to enable their detection and removal by phagocytes such as macrophages. Dysregulation of this process is thought to contribute to the pathogenesis and progression of chronic inflammatory disorders such as chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, allergic rhinitis and inflammatory bowel disease. Importantly, knowledge of the signalling pathways responsible for the induction and execution of granulocyte apoptosis and the phagocytic removal of apoptotic cells continues to increase and, with it, the potential for incisive pharmacological intervention. In this article, we highlight pharmacological strategies that could be used to drive the resolution of inflammation by augmenting apoptosis of inflammatory cells.
Original language | English |
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Pages (from-to) | 250-7 |
Number of pages | 8 |
Journal | Trends in Pharmacological Sciences |
Volume | 29 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2008 |
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Dive into the research topics of 'Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation'. Together they form a unique fingerprint.Projects
- 1 Finished
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Induction of neutrophil apoptosis and treatment of severe lung inflammation
1/09/07 → 29/02/12
Project: Research