Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period

W Goldmann, T Martin, J Foster, S Hughes, G Smith, K Hughes, M Dawson, N Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

Age at disease onset and rate of progression of transmissible spongiform encephalopathies in man, sheep and mice are modulated by the host genome, in particular by the PrP gene and its allelic forms. Analysis of the caprine PrP gene revealed several different alleles. Four PrP protein variants were found, three of which were goat specific with single amino acid changes at codons 142, 143 and 240. The fourth was identical to the most common sheep PrP protein variant (Ala136-Arg154-Gln171). The dimorphism at codon 142 (Ile --> Met) appeared to be associated with differing disease incubation periods in goats experimentally infected with isolates of bovine spongiform encephalopathy, sheep scrapie CH1641 or sheep-passaged ME7 scrapie.
Original languageEnglish
Pages (from-to)2885-91
Number of pages7
JournalJournal of General Virology
Volume77 ( Pt 11)
Publication statusPublished - Nov 1996

Keywords

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Codon
  • Encephalopathy, Bovine Spongiform
  • Goats
  • Haplotypes
  • Humans
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Open Reading Frames
  • Polymorphism, Genetic
  • PrPSc Proteins
  • Scrapie
  • Sheep

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