NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants

Zheng Qing Fu, Shunping Yan, Abdelaty Saleh, Wei Wang, James Ruble, Nodoka Oka, Rajinikanth Mohan, Steven H. Spoel, Yasuomi Tada, Ning Zheng, Xinnian Dong

Research output: Contribution to journalArticlepeer-review

Abstract

Salicylic acid (SA) is a plant immune signal produced after pathogen challenge to induce systemic acquired resistance. It is the only major plant hormone for which the receptor has not been firmly identified. Systemic acquired resistance in Arabidopsis requires the transcription cofactor nonexpresser of PR genes 1 (NPR1), the degradation of which acts as a molecular switch. Here we show that the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind SA with different affinities. NPR3 and NPR4 function as adaptors of the Cullin 3 ubiquitin E3 ligase to mediate NPR1 degradation in an SA-regulated manner. Accordingly, the Arabidopsis npr3 npr4 double mutant accumulates higher levels of NPR1, and is insensitive to induction of systemic acquired resistance. Moreover, this mutant is defective in pathogen effector-triggered programmed cell death and immunity. Our study reveals the mechanism of SA perception in determining cell death and survival in response to pathogen challenge.
Original languageEnglish
Pages (from-to)228–232
JournalNature
Volume486
Issue number7402
Early online date16 May 2012
DOIs
Publication statusPublished - 2012

Keywords

  • Plant Sciences
  • Molecular biology
  • Genetics
  • Genomics
  • Biochemistry

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