Nuclear envelope influences on cell-cycle progression

Vlastimil Srsen, Nadia Korfali, Eric C Schirmer

Research output: Contribution to journalArticlepeer-review

Abstract

The nuclear envelope is a complex double membrane system that serves as a dynamic interface between the nuclear and cytoplasmic compartments. Among its many roles is to provide an anchor for gene regulatory proteins on its nucleoplasmic surface and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions come from both inner and outer nuclear membrane NETs and appear to operate through several distinct mechanisms ranging from sequestration of gene-regulatory proteins to activating kinase cascades.
Original languageEnglish
Pages (from-to)1742-6
Number of pages5
JournalBiochemical Society Transactions
Volume39
Issue number6
DOIs
Publication statusPublished - 2011

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