Nuclear export complexes in the frame

Atlanta G Cook, Elena Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Protein and RNA molecules are exchanged between the nucleus and cytoplasm by members of the karyopherin beta family of transport factors. Karyopherins adopt a modular HEAT-repeat architecture and are regulated by the GTPase Ran. RanGTP acts as a signal for the nuclear compartment, dissociating molecular cargo from karyopherins that mediate nuclear import and promoting cargo uptake on those mediating nuclear export. After unraveling the mechanisms of nuclear import factors, structural studies have recently provided tremendous insights into nuclear export. The impact of RanGTP binding on the karyopherins ranges from large, global conformational changes to local, allosteric effects. A theme emerges where cargo recognition provides a molecular surveillance mechanism to prevent the transport of macromolecules in an inappropriate state.
Original languageEnglish
Pages (from-to)247-52
Number of pages6
JournalCurrent opinion in structural biology
Volume20
Issue number2
Early online date18 Feb 2010
DOIs
Publication statusPublished - 30 Apr 2010

Keywords

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Nucleus
  • Cytoplasm
  • Humans
  • Karyopherins
  • Nuclear Proteins
  • Nucleocytoplasmic Transport Proteins

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