Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

Ricardo de Francisco Strefezzi; José Guilherme Xavier; Silvia Regina Kleeb; José Luiz Catão-Dias

doi:10.1177/104063870902100608

Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

Ricardo de Francisco Strefezzi, José Guilherme Xavier, Silvia Regina Kleeb, José Luiz Catão-Dias

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

Original language	English
Pages (from-to)	821-5
Number of pages	5
Journal	Journal of Veterinary Diagnostic Investigation
Volume	21
Issue number	6
DOIs	https://doi.org/10.1177/104063870902100608
Publication status	Published - Nov 2009

Keywords

Age of Onset
Animals
Cell Nucleus/pathology
Dog Diseases/mortality
Dogs
Mast Cells/pathology
Neoplasm Staging/veterinary
Skin Neoplasms/mortality
Survival Rate
Survivors

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10.1177/104063870902100608

Cite this

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title = "Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors",

abstract = "Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.",

keywords = "Age of Onset, Animals, Cell Nucleus/pathology, Dog Diseases/mortality, Dogs, Mast Cells/pathology, Neoplasm Staging/veterinary, Skin Neoplasms/mortality, Survival Rate, Survivors",

author = "Strefezzi, {Ricardo de Francisco} and Xavier, {Jos{\'e} Guilherme} and Kleeb, {Silvia Regina} and Cat{\~a}o-Dias, {Jos{\'e} Luiz}",

year = "2009",

month = nov,

doi = "10.1177/104063870902100608",

language = "English",

volume = "21",

pages = "821--5",

journal = "Journal of Veterinary Diagnostic Investigation",

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publisher = "American Association of Veterinary Laboratory Diagnosticians",

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}

TY - JOUR

T1 - Nuclear morphometry in cytopathology

T2 - a prognostic indicator for canine cutaneous mast cell tumors

AU - Strefezzi, Ricardo de Francisco

AU - Xavier, José Guilherme

AU - Kleeb, Silvia Regina

AU - Catão-Dias, José Luiz

PY - 2009/11

Y1 - 2009/11

N2 - Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

AB - Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

KW - Age of Onset

KW - Animals

KW - Cell Nucleus/pathology

KW - Dog Diseases/mortality

KW - Dogs

KW - Mast Cells/pathology

KW - Neoplasm Staging/veterinary

KW - Skin Neoplasms/mortality

KW - Survival Rate

KW - Survivors

U2 - 10.1177/104063870902100608

DO - 10.1177/104063870902100608

M3 - Article

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EP - 825

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 6

ER -

Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

Abstract

Keywords

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