Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

Ricardo de Francisco Strefezzi, José Guilherme Xavier, Silvia Regina Kleeb, José Luiz Catão-Dias

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

Original languageEnglish
Pages (from-to)821-5
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume21
Issue number6
DOIs
Publication statusPublished - Nov 2009

Keywords / Materials (for Non-textual outputs)

  • Age of Onset
  • Animals
  • Cell Nucleus/pathology
  • Dog Diseases/mortality
  • Dogs
  • Mast Cells/pathology
  • Neoplasm Staging/veterinary
  • Skin Neoplasms/mortality
  • Survival Rate
  • Survivors

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