Nuclear pore density controls heterochromatin reorganization during senescence

Charlene Boumendil, Priya Hari, Karl C.F. Olsen, Juan Carlos Acosta, Wendy A. Bickmore

Research output: Contribution to journalArticlepeer-review

Abstract

During oncogene-induced senescence (OIS), heterochromatin is lost from the nuclear periphery and forms internal senescence-associated heterochromatin foci (SAHFs). We show that an increased nuclear pore density during OIS is responsible for SAHF formation. In particular, the nucleoporin TPR is necessary for both formation and maintenance of SAHFs. Loss of SAHFs does not affect cell cycle arrest but abrogates the senescence-associated secretory phenotype—a program of inflammatory cytokine gene activation. Our results uncover a previously unknown role of nuclear pores in heterochromatin reorganization in mammalian nuclei and demonstrate the importance of heterochromatin organization for a specific gene activation program.
Original languageEnglish
Pages (from-to)144-149
JournalGenes & Development
Volume33
Issue number3-4
Early online date28 Jan 2019
DOIs
Publication statusPublished - 1 Feb 2019

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  • HGU Core

    Bickmore, W.

    MRC

    1/04/1831/03/23

    Project: Research

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