Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer

Eric C. Schirmer, Leena Latonen, Sylvain Tollis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through the microscope for close to 200 years. Changes in nuclear size characteristically occur in many cancer types when the cells metastasize. This was initially discarded as contributing to the metastatic spread because, depending on tumor types, both increases and decreases in nuclear size could correlate with increased metastasis. However, recent work on nuclear mechanics and the connectivity between chromatin, the nucleoskeleton, and the cytoskeleton indicate that changes in this connectivity can have profound impacts on cell mobility and invasiveness. Critically, a recent study found that reversing tumor type-dependent nuclear size changes correlated with reduced cell migration and invasion. Accordingly, it seems appropriate to now revisit possible contributory roles of nuclear size changes to metastasis.

Original languageEnglish
Article number1022723
Number of pages17
JournalFrontiers in Cell and Developmental Biology
Volume10
DOIs
Publication statusPublished - 10 Oct 2022

Keywords

  • cancer
  • cell migration
  • karyoplasmic ratio
  • lamin
  • metastasis
  • NET
  • nuclear envelope
  • nuclear size

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