Nucleotide sequence of equine caspase-1 cDNA

S Wardlow, M N Penha-Goncalves, D J Argyle, D E Onions, L Nicolson

Research output: Contribution to journalArticlepeer-review

Abstract

Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. We report the cloning and sequencing of equine caspase-1 cDNA. Equine caspase-1 is 405 amino acids in length and has 72% and 63% identity to human and mouse caspase-1, respectively, at the amino acid level. Sites of proteolytic cleavage and catalytic activity as identified in human caspase-1, are conserved.
Original languageEnglish
Pages (from-to)133-7
Number of pages5
JournalDNA Sequence
Volume10
Issue number2
Publication statusPublished - 1999

Keywords

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caspase 1
  • DNA, Complementary
  • Equidae
  • Humans
  • Mice
  • Molecular Sequence Data

Fingerprint Dive into the research topics of 'Nucleotide sequence of equine caspase-1 cDNA'. Together they form a unique fingerprint.

Cite this