Nuts and bolts of psychiatric genetics: building on the Human Genome Project

Kathryn Evans, Walter Muir, Douglas Blackwood, D J Porteous

Research output: Contribution to journalArticlepeer-review

Abstract

Schizophrenia and bipolar affective disorder are chronic, disabling illnesses that together affect 2% of the population. Genetic factors are known to be important in their development, but there are, as yet, no confirmed susceptibility genes. Here we discuss important issues in terms of alternative genetic strategies (linkage, association and/or cytogenetics) in the identification of candidate genes for the major psychoses. We discuss the impact of the Human Genome Project, the role of comparative genetics in finding and testing positional candidates, and the prospects for rational drug design and personalized medicine.
Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalTrends in Genetics
Volume17
Issue number1
Publication statusPublished - 2001

Keywords

  • Female
  • Genetic Linkage
  • Human Genome Project
  • Humans
  • Male
  • Mental Disorders
  • Pedigree

Fingerprint

Dive into the research topics of 'Nuts and bolts of psychiatric genetics: building on the Human Genome Project'. Together they form a unique fingerprint.

Cite this