Objective quantification of muscle and fat in human dystrophic muscle by magnetic resonance image analysis

J Phoenix, D Betal, N Roberts, TR Helliwell, RHT Edwards

Research output: Contribution to journalArticlepeer-review

Abstract

Information about changes in muscle composition has to date been primarily restricted to histological examination of biopsy samples or qualitative assessment of images obtained using a variety of techniques (e.g., ultrasound, CT, and MRI). We describe the development of a quantitative method far the analysis of muscle composition using MR T-2 relaxation time mapping and image analysis. This approach provides an objective means of studying muscle and, when used in conjunction with force production measurements, may provide an accurate measure of response to muscle therapy. (C) 1996 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)302-310
Number of pages9
JournalMuscle & Nerve
Volume19
Issue number3
Publication statusPublished - Mar 1996

Keywords

  • DUCHENNE MUSCULAR-DYSTROPHY
  • CROSS-SECTIONAL AREA
  • SKELETAL-MUSCLE
  • DISEASED MUSCLE
  • ULTRASOUND
  • STRENGTH
  • TRANSPLANTATION
  • TOMOGRAPHY
  • CHILDREN
  • TISSUE

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