Observations on the pancreas of cattle deficient in copper

B F Fell, L J Farmer, C Farquharson, I Bremner, D S Graca

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Lesions were found in the pancreas of clinically normal cattle of low copper status. In comparison with the pancreas of cattle with normal hepatic copper reserves, the abnormalities were an increase in the dry matter content and reduction in the concentrations of protein and copper in the wet tissue. Cytochrome oxidase activity and protein-to-RNA ratio were also reduced. Histologically, there were defects in acinar basement membranes, splitting and disorganization of acini, cellular atrophy and dissociation, and stromal proliferation. The pancreatic ductular system did not show atrophy or disorganization.
Original languageEnglish
Pages (from-to)573-90
Number of pages18
JournalJournal of Comparative Pathology
Issue number4
Publication statusPublished - Oct 1985

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Cattle
  • Cattle Diseases
  • Copper
  • DNA
  • Deficiency Diseases
  • Pancreas
  • Proteins
  • RNA


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