Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni, Joshua M Brickman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.
Original languageEnglish
Pages (from-to)547-8
Number of pages2
JournalDevelopmental Cell
Issue number6
Publication statusPublished - 24 Jun 2013

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Blastocyst
  • Embryonic Stem Cells
  • Endoderm
  • Female
  • Gene Expression Regulation, Developmental
  • Male
  • Octamer Transcription Factor-3
  • Pregnancy


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