Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni, Joshua M Brickman

Research output: Contribution to journalArticlepeer-review

Abstract

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.
Original languageEnglish
Pages (from-to)547-8
Number of pages2
JournalDevelopmental Cell
Volume25
Issue number6
DOIs
Publication statusPublished - 24 Jun 2013

Keywords

  • Animals
  • Blastocyst
  • Embryonic Stem Cells
  • Endoderm
  • Female
  • Gene Expression Regulation, Developmental
  • Male
  • Octamer Transcription Factor-3
  • Pregnancy

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