Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni; Joshua M Brickman

doi:10.1016/j.devcel.2013.06.002

Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni, Joshua M Brickman

Research output: Contribution to journal › Article › peer-review

Abstract

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

Original language	English
Pages (from-to)	547-8
Number of pages	2
Journal	Developmental Cell
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2013.06.002
Publication status	Published - 24 Jun 2013

Keywords / Materials (for Non-textual outputs)

Animals
Blastocyst
Embryonic Stem Cells
Endoderm
Female
Gene Expression Regulation, Developmental
Male
Octamer Transcription Factor-3
Pregnancy

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10.1016/j.devcel.2013.06.002

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title = "Oct4: the final frontier, differentiation defining pluripotency",

abstract = "The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.",

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AU - Brickman, Joshua M

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AB - The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

KW - Animals

KW - Blastocyst

KW - Embryonic Stem Cells

KW - Endoderm

KW - Female

KW - Gene Expression Regulation, Developmental

KW - Male

KW - Octamer Transcription Factor-3

KW - Pregnancy

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DO - 10.1016/j.devcel.2013.06.002

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JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Oct4: the final frontier, differentiation defining pluripotency

Abstract

Keywords / Materials (for Non-textual outputs)

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