Ocular Pathology of Cerebral Malaria

Valerie Ann White, Valentina Barrera, Ian James Callum MacCormick

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Investigation of post-mortem eyes from children with malarial retinopathy has helped to explain the retinal pathology of cerebral malaria, and also demonstrated histological associations between evolving retinal pathogenesis-visible clinically-and similar cerebral features which can only be examined at autopsy. The pathology of malarial retinopathy has been well-described and correlates with brain pathology. Some clinical and pathological features are associated with outcome. This chapter describes the materials and methods needed to study the pathological features of malarial retinopathy. Some are common to histopathology in general, but accurate spatial correlation between retinal features observed in life and their associated pathology in post-mortem specimens requires special techniques.

Original languageEnglish
Title of host publication Malaria Immunology
Subtitle of host publicationTargeting the Surface of Infected Erythrocytes
EditorsAnja Tatiana Ramstedt Jensen, Lars Hviid
Place of PublicationNew York, NY
PublisherHumana Press
Pages749-763
Number of pages15
Volume2470
ISBN (Electronic)9781071621899
ISBN (Print)9781071621882
DOIs
Publication statusPublished - 27 Jul 2022

Publication series

NameMethods in molecular biology (Clifton, N.J.)
PublisherHumana Press
ISSN (Print)1064-3745

Keywords / Materials (for Non-textual outputs)

  • Child
  • Humans
  • Malaria, Cerebral
  • Malaria, Falciparum/pathology
  • Retina/pathology
  • Retinal Diseases/etiology

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