Of mice, men and motor neurons

Helen J Newbery, Catherine M Abbott

Research output: Contribution to journalArticlepeer-review

Abstract

The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple models.
Original languageEnglish
Pages (from-to)S2-S6
Number of pages5
JournalTrends in Genetics
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2001

Keywords

  • Amyotrophic Lateral Sclerosis
  • motor neuron
  • transgenic
  • superoxide dismutase
  • neurofilament
  • wasted
  • neuromuscular degeneration

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