Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

Zoi Michailidou; Michael D Jensen; Daniel A Dumesic; Karen E Chapman; Jonathan R Seckl; Brian R Walker; Nicholas M Morton

doi:10.1038/oby.2007.618

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

Zoi Michailidou, Michael D Jensen, Daniel A Dumesic, Karen E Chapman, Jonathan R Seckl, Brian R Walker, Nicholas M Morton

Research output: Contribution to journal › Article › peer-review

Abstract

In ideopathic obesity, there is evidence that enhanced cortisol regeneration within abdominal subcutaneous adipose tissue may contribute to adiposity and metabolic disease. Whether the cortisol regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), or glucocorticoid receptor (GRalpha) levels are altered in other adipose depots remains uncertain. Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome.

Original language	English
Pages (from-to)	1155-63
Number of pages	9
Journal	Obesity
Volume	15
Issue number	5
DOIs	https://doi.org/10.1038/oby.2007.618
Publication status	Published - 2007

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10.1038/oby.2007.618

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title = "Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity",

abstract = "In ideopathic obesity, there is evidence that enhanced cortisol regeneration within abdominal subcutaneous adipose tissue may contribute to adiposity and metabolic disease. Whether the cortisol regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), or glucocorticoid receptor (GRalpha) levels are altered in other adipose depots remains uncertain. Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome.",

author = "Zoi Michailidou and Jensen, {Michael D} and Dumesic, {Daniel A} and Chapman, {Karen E} and Seckl, {Jonathan R} and Walker, {Brian R} and Morton, {Nicholas M}",

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AU - Michailidou, Zoi

AU - Jensen, Michael D

AU - Dumesic, Daniel A

AU - Chapman, Karen E

AU - Seckl, Jonathan R

AU - Walker, Brian R

AU - Morton, Nicholas M

PY - 2007

Y1 - 2007

N2 - In ideopathic obesity, there is evidence that enhanced cortisol regeneration within abdominal subcutaneous adipose tissue may contribute to adiposity and metabolic disease. Whether the cortisol regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), or glucocorticoid receptor (GRalpha) levels are altered in other adipose depots remains uncertain. Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome.

AB - In ideopathic obesity, there is evidence that enhanced cortisol regeneration within abdominal subcutaneous adipose tissue may contribute to adiposity and metabolic disease. Whether the cortisol regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), or glucocorticoid receptor (GRalpha) levels are altered in other adipose depots remains uncertain. Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome.

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DO - 10.1038/oby.2007.618

M3 - Article

C2 - 17495191

VL - 15

SP - 1155

EP - 1163

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

Abstract

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