Omission of radiation therapy after breast conserving surgery for older women at low-risk of local recurrence: One option among many

Icro Meattini, Ian H. Kunkler

Research output: Contribution to journalShort surveypeer-review

Abstract / Description of output

This editorial discusses the evolving landscape of early-stage breast cancer treatment, emphasizing the need to tailor therapies based on disease biology and genomic approaches. The focus is on the reconsideration of postoperative radiation therapy (RT) for older patients with low-risk, hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer. Recent trials show modest long-term local recurrence rates with the omission of RT after BCS in certain cases, challenging the traditional approach. The commentary calls for continued research on predictive tests for treatment response and advocates for a multidisciplinary approach to decision-making, considering factors like quality of life. The nuanced risk/benefit ratio of RT in older patients is explored, emphasizing the importance of comprehensive assessment for optimal therapy.
Original languageEnglish
Article number108058
Pages (from-to)108058
JournalEuropean Journal of Surgical Oncology (EJSO)
Volume50
Issue number4
DOIs
Publication statusPublished - 22 Feb 2024

Keywords / Materials (for Non-textual outputs)

  • Breast cancer
  • elderly
  • health-related quality of life
  • radiotheraphy
  • endocrine therapy
  • optimisation

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