On the fixation or nonfixation of inversions under epistatic selection

Brian Charlesworth; Thomas Flatt

doi:10.1111/mec.16026

On the fixation or nonfixation of inversions under epistatic selection

Brian Charlesworth, Thomas Flatt

School of Biological Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Several recent publications have stated that epistatic fitness interactions cause the fixation of inversions that suppress recombination among the loci involved. Under this type of selection, however, the suppression of recombination in an inversion heterozygote can create a form of heterozygote advantage, which prevents the inversion from becoming fixed by selection. This process has been explicitly modelled by previous workers.

Original language	English
Number of pages	2
Journal	Molecular Ecology
DOIs	https://doi.org/10.1111/mec.16026
Publication status	Published - 4 Jul 2021

Keywords

balanced polymorphism
epstasis
fitness
inversions
linkage disequilibrium recombination

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abstract = "Several recent publications have stated that epistatic fitness interactions cause the fixation of inversions that suppress recombination among the loci involved. Under this type of selection, however, the suppression of recombination in an inversion heterozygote can create a form of heterozygote advantage, which prevents the inversion from becoming fixed by selection. This process has been explicitly modelled by previous workers.",

keywords = "balanced polymorphism, epstasis, fitness, inversions, linkage disequilibrium recombination",

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AU - Charlesworth, Brian

AU - Flatt, Thomas

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N2 - Several recent publications have stated that epistatic fitness interactions cause the fixation of inversions that suppress recombination among the loci involved. Under this type of selection, however, the suppression of recombination in an inversion heterozygote can create a form of heterozygote advantage, which prevents the inversion from becoming fixed by selection. This process has been explicitly modelled by previous workers.

AB - Several recent publications have stated that epistatic fitness interactions cause the fixation of inversions that suppress recombination among the loci involved. Under this type of selection, however, the suppression of recombination in an inversion heterozygote can create a form of heterozygote advantage, which prevents the inversion from becoming fixed by selection. This process has been explicitly modelled by previous workers.

KW - balanced polymorphism

KW - epstasis

KW - fitness

KW - inversions

KW - linkage disequilibrium recombination

U2 - 10.1111/mec.16026

DO - 10.1111/mec.16026

M3 - Comment/debate

JO - Molecular Ecology

JF - Molecular Ecology

SN - 0962-1083

ER -

On the fixation or nonfixation of inversions under epistatic selection

Abstract

Keywords

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