On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage

D P Lane; C A Midgley; T R Hupp; X Lu; B Vojtesek; S M Picksley

doi:10.1098/rstb.1995.0013

On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage

D P Lane, C A Midgley, T R Hupp, X Lu, B Vojtesek, S M Picksley

Research output: Contribution to journal › Article › peer-review

Abstract

The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage results in the accumulation of biologically active p53. This response is potentially lethal and is therefore highly regulated. By using both biochemical and cell biological approaches a number of discrete control pathways have been identified. These include analysis of cellular and viral proteins that bind to p53 to inactivate its function, the discovery of cells with defects in the p53 activation pathway and the analysis of an allosteric regulation of p53 function controlled by phosphorylation.

Original language	English
Pages (from-to)	83-7
Number of pages	5
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	347
Issue number	1319
DOIs	https://doi.org/10.1098/rstb.1995.0013
Publication status	Published - 30 Jan 1995

Keywords / Materials (for Non-textual outputs)

Amino Acid Sequence
Animals
DNA Damage
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Molecular Sequence Data

Access to Document

10.1098/rstb.1995.0013

Cite this

@article{4072ebaeab6749259ebdfb178398e494,

title = "On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage",

abstract = "The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage results in the accumulation of biologically active p53. This response is potentially lethal and is therefore highly regulated. By using both biochemical and cell biological approaches a number of discrete control pathways have been identified. These include analysis of cellular and viral proteins that bind to p53 to inactivate its function, the discovery of cells with defects in the p53 activation pathway and the analysis of an allosteric regulation of p53 function controlled by phosphorylation.",

keywords = "Amino Acid Sequence, Animals, DNA Damage, Gene Expression Regulation, Neoplastic, Genes, p53, Humans, Molecular Sequence Data",

author = "Lane, {D P} and Midgley, {C A} and Hupp, {T R} and X Lu and B Vojtesek and Picksley, {S M}",

year = "1995",

month = jan,

day = "30",

doi = "10.1098/rstb.1995.0013",

language = "English",

volume = "347",

pages = "83--7",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0962-8436",

publisher = "ROYAL SOC",

number = "1319",

}

TY - JOUR

T1 - On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage

AU - Lane, D P

AU - Midgley, C A

AU - Hupp, T R

AU - Lu, X

AU - Vojtesek, B

AU - Picksley, S M

PY - 1995/1/30

Y1 - 1995/1/30

N2 - The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage results in the accumulation of biologically active p53. This response is potentially lethal and is therefore highly regulated. By using both biochemical and cell biological approaches a number of discrete control pathways have been identified. These include analysis of cellular and viral proteins that bind to p53 to inactivate its function, the discovery of cells with defects in the p53 activation pathway and the analysis of an allosteric regulation of p53 function controlled by phosphorylation.

AB - The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage results in the accumulation of biologically active p53. This response is potentially lethal and is therefore highly regulated. By using both biochemical and cell biological approaches a number of discrete control pathways have been identified. These include analysis of cellular and viral proteins that bind to p53 to inactivate its function, the discovery of cells with defects in the p53 activation pathway and the analysis of an allosteric regulation of p53 function controlled by phosphorylation.

KW - Amino Acid Sequence

KW - Animals

KW - DNA Damage

KW - Gene Expression Regulation, Neoplastic

KW - Genes, p53

KW - Humans

KW - Molecular Sequence Data

U2 - 10.1098/rstb.1995.0013

DO - 10.1098/rstb.1995.0013

M3 - Article

C2 - 7746859

SN - 0962-8436

VL - 347

SP - 83

EP - 87

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

IS - 1319

ER -

On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this