Abstract / Description of output
RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
Original language | English |
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Pages (from-to) | 75-9 |
Number of pages | 5 |
Journal | Transgenic Research |
Volume | 13 |
Issue number | 1 |
Publication status | Published - Feb 2004 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Gene Silencing
- Gene Transfer Techniques
- Mice
- Mice, Transgenic
- RNA
- RNA Processing, Post-Transcriptional
- Transfection
- Transgenes