On the use of post-transcriptional processing elements in transgenes

C B A Whitelaw, L Hiripi, E Farini, M L Opsahl, Z Bosze

Research output: Contribution to journalArticlepeer-review

Abstract

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
Original languageEnglish
Pages (from-to)75-9
Number of pages5
JournalTransgenic Research
Volume13
Issue number1
Publication statusPublished - Feb 2004

Keywords

  • Animals
  • Gene Silencing
  • Gene Transfer Techniques
  • Mice
  • Mice, Transgenic
  • RNA
  • RNA Processing, Post-Transcriptional
  • Transfection
  • Transgenes

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