RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
|Number of pages||5|
|Publication status||Published - Feb 2004|
- Gene Silencing
- Gene Transfer Techniques
- Mice, Transgenic
- RNA Processing, Post-Transcriptional