Oncometabolites: linking altered metabolism with cancer

Ming Yang, Tomoyoshi Soga, Patrick J Pollard

Research output: Contribution to journalArticlepeer-review

Abstract

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
Original languageEnglish
Pages (from-to)3652-8
Number of pages7
JournalJournal of Clinical Investigation
Volume123
Issue number9
DOIs
Publication statusPublished - 3 Sep 2013

Keywords

  • animals
  • carboxylic acids
  • Cell Transformation, Neoplastic
  • Epigenesis, Genetic
  • Fumarate Hydratase
  • HUMANS
  • Metabolic Networks and Pathways
  • MUTATION
  • Neoplasms
  • Succinate Dehydrogenase
  • Tumor Markers, Biological

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