One for all and all for one: Thymic epithelial stem cells and regeneration

C. Clare Blackburn, Nancy R. Manley, Donald B. Palmer, Richard L. Boyd, Graham Anderson, Mary A. Ritter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

It has long been believed that the thymic epithelial microenvironment originates from both the endodermal and ectodermal germ cell layers. However, a growing body of evidence indicates that such a dual origin is not the case, and that the diverse thymic epithelial populations all develop from a common epithelial stem cell. This article explores these data, investigates the identity of such cells and the signals that might control their expansion and differentiation, and considers the possibility of stem cell transplantation for thymic regeneration.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalTrends in Immunology
Volume23
Issue number8
DOIs
Publication statusPublished - 1 Aug 2002

Keywords

  • thymus
  • thymic epithelial cell
  • stem cell
  • epithelium
  • ontogeny
  • thymic differentiation
  • T cell development

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