One-pot synthesis of 2,3,4,5,6-pentasubstituted tetrahydropyrans using lithiation-borylation, allylation and Prins cyclisation reactions

Stephen Thomas, Varinder K. Aggarwal, Adeem Mahmood, Jose Ramon Suarez

Research output: Contribution to journalArticlepeer-review

Abstract

2,3,4,5,6-Pentasubstituted tetrahydropyrans have been prepared in good yield (42–57%) with excellent dr (>95:5) and er (>95:5) using a one-pot lithiation–borylation, allylation and Prins cyclisation reaction.
Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Lithiation–borylation
  • Allylation
  • Prins cyclisation
  • Tandem
  • Boronic ester

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