One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)

ChILDEU study group, Steve Cunningham, Catriona Graham, Morag MacLean, Paul Aurora, Michael Ashworth, Angelo Barbato, Alistair Calder, Julia Carlens, Annick Clement, Meike Hengst, Birgit Kammer, Nural Kiper, Katarzyna Krenke, Kai Kronfield, Joanna Lange, Julia Ley-Zaporozhan , Andrew G Nicholson, Simone Reu, Traudl WesselakMartin Wetzke, Andrew Bush, Nicolaus Schwerk, Matthias Griese

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We performed a prospective, observational, cohort study of children newly diagnosed with children’s interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3–7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO2) median 92% (IQR 88–96). Death (n=20, 16%) was the most common in those <6 months of age with SpO2<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8–12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.
Original languageEnglish
Pages (from-to)172-175
JournalThorax
Volume75
Issue number2
Early online date20 Nov 2019
DOIs
Publication statusPublished - Feb 2020

Fingerprint

Dive into the research topics of 'One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)'. Together they form a unique fingerprint.

Cite this