Ongoing burden and recent trends in severe hospitalised hypoglycaemia events in people with type 1 and type 2 diabetes in Scotland: A nationwide cohort study 2016-2022

William Berthon*, Stuart J McGurnaghan, Luke A K Blackbourn, Joseph Mellor, Fraser W Gibb, Simon R. Heller, Brian Kennon, Rory J McCrimmon, Sam Philip, Naveed Sattar, Paul M McKeigue, Helen M Colhoun, Scottish Diabetes Research Network Epidemiology Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIMS: We examined severe hospitalised hypoglycaemia (SHH) rates in people with type 1 and type 2 diabetes in Scotland during 2016-2022, stratifying by sociodemographics.

METHODS: Using the Scottish National diabetes register (SCI-Diabetes), we identified people with type 1 and type 2 diabetes alive anytime during 2016-2022. SHH events were determined through linkage to hospital admission and death registry data. We calculated annual SHH rates overall and by age, sex, and socioeconomic status. Summary estimates of time and stratum effects were obtained by fitting adjusted generalised additive models using R package mgcv.

RESULTS: Rates for those under 20 with type 1 diabetes reached their minimum at the 2020-2021 transition, 30% below the study period average. A gradual decline over time also occurred among 20-49-year-olds with type 1 diabetes. Overall, females had 15% higher rates than males with type 2 diabetes (rate ratio 1.15, 95% CI 1.08-1.22). People in the most versus least deprived quintile experienced 2.58 times higher rates (95% CI 2.27-2.93) in type 1 diabetes and 2.33 times higher (95% CI 2.08-2.62) in type 2 diabetes.

CONCLUSIONS: Despite advances in care, SHH remains a significant problem in diabetes. Future efforts must address the large socioeconomic disparities in SHH risks.

Original languageEnglish
Article number111642
Number of pages11
JournalDiabetes Research and Clinical Practice
Volume210
Early online date27 Mar 2024
DOIs
Publication statusPublished - 1 Apr 2024

Keywords / Materials (for Non-textual outputs)

  • Type 1 diabetes
  • Type 2 diabetes
  • Hypoglycaemia
  • Hospital admission
  • Population-based studies
  • Epidemiology

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