Ontogeny of the Haematopoietic System

Aldo Ciau-Uitz, Roger Patient, Alexander Medvinsky

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

As for most other tissues and organs, the hematopoietic system is formed during gastrulation and organogenesis. The mesoderm gives rise to hematovascular progenitors which through cellular intermediates go on to differentiate into blood. The hematopoietic system develops in waves: in all vertebrate species, early transitory embryonic waves are gradually replaced by a permanent adult hierarchy which persists throughout the animal’s lifespan. During development, hematopoietic stem cells (HSCs) undergo step-wise differentiation changing their phenotype, functional properties and locations. Complex cell movements, molecular signalling and interplay of transcription factors underlie these processes. This Chapter focuses on tissue origin and mechanisms underpinning the development of the adult hematopoietic system in light of analysis of different vertebrate models.

Original languageEnglish
Title of host publicationEncyclopedia of Immunobiology
EditorsMichael J. H. Ratcliffe
PublisherElsevier
Pages1-14
Number of pages14
Volume1
ISBN (Print)978-0-08-092152-5
DOIs
Publication statusE-pub ahead of print - 9 May 2016

Keywords

  • embryo
  • mouse
  • Xenopus
  • Zebrafish
  • embryonic hematopoiesis
  • adult haematopoiesis
  • hemangioblast
  • hematogenic endothelium
  • hemogenic endothelium
  • AGM region
  • dorsal aorta
  • ; intra-aortic clusters
  • yolk sac
  • fetal liver
  • HSC
  • preHSC
  • proHSC

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