Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach

DA Oyarzun, Brian Ingalls, Dimitrios Kalamatianos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthet- ical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time- optimal control.
Original languageEnglish
Title of host publicationFoundations of Systems Biology and Engineering (FOSBE 2007)
Pages491-496
Number of pages6
Publication statusPublished - 2007

Keywords

  • metabolic pathways,metabolic regulation,optimal control

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