Abstract / Description of output
In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthet- ical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time- optimal control.
| Original language | English |
|---|---|
| Title of host publication | Foundations of Systems Biology and Engineering (FOSBE 2007) |
| Pages | 491-496 |
| Number of pages | 6 |
| Publication status | Published - 2007 |
Keywords / Materials (for Non-textual outputs)
- metabolic pathways,metabolic regulation,optimal control