Abstract
Interest in the inhibition of peroxiredoxin has been revitalised by their recently identified role in signalling cascades. Here, the synthesis and analysis of novel analogues of the peroxiredoxin inhibitor conoidin A is described. Computational methods are used to rationalise the generated SAR data. These studies lead to a proposed binding mode for this class of compounds that will aid the design of second generation inhibitors.
Original language | English |
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Pages (from-to) | 41-45 |
Number of pages | 5 |
Journal | ChemMedChem |
Volume | 5 |
Issue number | 1 |
Early online date | 27 Nov 2009 |
DOIs | |
Publication status | Published - 4 Jan 2010 |
Keywords / Materials (for Non-textual outputs)
- conoidin A
- inhibitors
- molecular modeling
- peroxiredoxin
- Toxoplasma gondii
- TOXOPLASMA-GONDII
- HYDROGEN-PEROXIDE
- ANTIOXIDANT
- DEFENSE
- MECHANISMS
- TARGETS