Optimisation of Conoidin A, a Peroxiredoxin Inhibitor

Gu Liu*, Catherine H. Botting, Kathryn M. Evans, Jeffrey G. A. Walton, Guogang Xu, Alexandra M. Z. Slawin, Nicholas J. Westwood

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Interest in the inhibition of peroxiredoxin has been revitalised by their recently identified role in signalling cascades. Here, the synthesis and analysis of novel analogues of the peroxiredoxin inhibitor conoidin A is described. Computational methods are used to rationalise the generated SAR data. These studies lead to a proposed binding mode for this class of compounds that will aid the design of second generation inhibitors.
Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalChemMedChem
Volume5
Issue number1
Early online date27 Nov 2009
DOIs
Publication statusPublished - 4 Jan 2010

Keywords

  • conoidin A
  • inhibitors
  • molecular modeling
  • peroxiredoxin
  • Toxoplasma gondii
  • TOXOPLASMA-GONDII
  • HYDROGEN-PEROXIDE
  • ANTIOXIDANT
  • DEFENSE
  • MECHANISMS
  • TARGETS

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