Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

ADVANCE Collaborative Grp, G-D Batty, Q. Li, R. Huxley, S. Zoungas, B-A. Taylor, B. Neal, B. de Galan, M. Woodward, S-B Harrap, S. Colagiuri, A. Patel, J. Chalmers

Research output: Contribution to journalArticlepeer-review


Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline. (C) 2011 Elsevier Masson SAS. All rights reserved.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalEuropean Psychiatry
Issue number1
Publication statusPublished - Jan 2013

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