Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope

Eric C Schirmer; Larry Gerace

doi:10.1186/gb-2002-3-4-reviews1008

Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope

Eric C Schirmer, Larry Gerace

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.

Original language	English
Article number	reviews1008-reviews1008.4
Journal	Genome Biology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1186/gb-2002-3-4-reviews1008
Publication status	Published - 2002

Keywords

Animals
Cell Fractionation
Membrane Proteins
Nuclear Envelope
Nuclear Proteins
Proteome

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10.1186/gb-2002-3-4-reviews1008

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title = "Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope",

abstract = "Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.",

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KW - Animals

KW - Cell Fractionation

KW - Membrane Proteins

KW - Nuclear Envelope

KW - Nuclear Proteins

KW - Proteome

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DO - 10.1186/gb-2002-3-4-reviews1008

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Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope

Abstract

Keywords

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