Organization of brain complexity--synapse proteome form and function

A. J. Pocklington, J. D. Armstrong, S. G. N. Grant

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Proteomic study of the synapse has generated an extensive list of molecular components, revealing one of the most complex functional systems currently known to cell biology. While fundamental to neural information processing, behaviour and disease, the molecular organisation of the synapse and its relation to higher-level function has yet to be clearly understood. Neurotransmitter receptor complexes, such as the N-methyl-D-aspartate receptor complex (NRC/MASC), are major components of the synaptic proteome. We have recently completed a detailed study of MASC, its functional organisation and involvement in behaviour and disease. This pointed to simple design principles underlying synaptic organisation. Drawing together the results of proteomic and analytical study, we sketch out a model for synaptic functional organisation.
Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalBriefings in functional genomics & proteomics
Issue number1
Publication statusPublished - 2006


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