Osteoarthritis cartilage histopathology: grading and staging

K P H Pritzker; S Gay; S A Jimenez; K Ostergaard; J-P Pelletier; P A Revell; D Salter; W B van den Berg

doi:10.1016/j.joca.2005.07.014

Osteoarthritis cartilage histopathology: grading and staging

K P H Pritzker, S Gay, S A Jimenez, K Ostergaard, J-P Pelletier, P A Revell, D Salter, W B van den Berg

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.

DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.

RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.

CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.

Original language	English
Pages (from-to)	13-29
Number of pages	17
Journal	Osteoarthritis and Cartilage
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.joca.2005.07.014
Publication status	Published - Jan 2006

Keywords / Materials (for Non-textual outputs)

Animals
Arthroscopy
Biological Markers
Bone Remodeling
Cartilage, Articular
Cell Division
Chondrocytes
Disease Models, Animal
Disease Progression
Humans
Hypertrophy
Joints
Osteoarthritis
Reproducibility of Results
Sclerosis
Terminology as Topic

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10.1016/j.joca.2005.07.014

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title = "Osteoarthritis cartilage histopathology: grading and staging",

abstract = "OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.",

keywords = "Animals, Arthroscopy, Biological Markers, Bone Remodeling, Cartilage, Articular, Cell Division, Chondrocytes, Disease Models, Animal, Disease Progression, Humans, Hypertrophy, Joints, Osteoarthritis, Reproducibility of Results, Sclerosis, Terminology as Topic",

author = "Pritzker, {K P H} and S Gay and Jimenez, {S A} and K Ostergaard and J-P Pelletier and Revell, {P A} and D Salter and {van den Berg}, {W B}",

year = "2006",

month = jan,

doi = "10.1016/j.joca.2005.07.014",

language = "English",

volume = "14",

pages = "13--29",

journal = "Osteoarthritis and Cartilage",

issn = "1063-4584",

publisher = "W.B. Saunders Company",

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}

TY - JOUR

T1 - Osteoarthritis cartilage histopathology

T2 - grading and staging

AU - Pritzker, K P H

AU - Gay, S

AU - Jimenez, S A

AU - Ostergaard, K

AU - Pelletier, J-P

AU - Revell, P A

AU - Salter, D

AU - van den Berg, W B

PY - 2006/1

Y1 - 2006/1

N2 - OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.

AB - OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.

KW - Animals

KW - Arthroscopy

KW - Biological Markers

KW - Bone Remodeling

KW - Cartilage, Articular

KW - Cell Division

KW - Chondrocytes

KW - Disease Models, Animal

KW - Disease Progression

KW - Humans

KW - Hypertrophy

KW - Joints

KW - Osteoarthritis

KW - Reproducibility of Results

KW - Sclerosis

KW - Terminology as Topic

U2 - 10.1016/j.joca.2005.07.014

DO - 10.1016/j.joca.2005.07.014

M3 - Article

C2 - 16242352

SN - 1063-4584

VL - 14

SP - 13

EP - 29

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 1

ER -

Osteoarthritis cartilage histopathology: grading and staging

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this