Osteoporosis Associated with Neutralizing Autoantibodies against Osteoprotegerin

Philip Riches, Euan McRorie, William D Fraser, Catherine Determann, Rob van't Hof, Stuart H Ralston

Research output: Contribution to journalArticlepeer-review

Abstract

Autoantibodies against osteoprotegerin, which block the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor (NF)-kappaB (RANK), were identified in a man with celiac disease who presented with severe osteoporosis and high bone turnover. The osteoporosis did not respond to the treatment of his celiac disease but was completely reversed by bisphosphonate therapy. Autoantibodies against osteoprotegerin were detected in three additional patients with celiac disease. Such autoantibodies may be associated with the development of high-turnover osteoporosis, but whether autoantibodies against osteoprotegerin commonly contribute to the pathogenesis of osteoporosis in patients with celiac disease remains to be determined.
Original languageEnglish
Pages (from-to)1459-1465
Number of pages7
JournalNew England Journal of Medicine
Volume361
Issue number15
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Adult
  • Autoantibodies
  • Autoimmune Diseases
  • Biological Markers
  • Bone Density
  • Bone Remodeling
  • Celiac Disease
  • Diet, Gluten-Free
  • Humans
  • Hypothyroidism
  • Immunoglobulin A
  • Male
  • Osteoporosis
  • Osteoprotegerin
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Transglutaminases

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