Outbreak of acute hepatitis C following the use of anti-hepatitis C virus--screened intravenous immunoglobulin therapy

C J Healey, N K Sabharwal, J Daub, F Davidson, P L Yap, K A Fleming, R W Chapman, P Simmonds, H Chapel

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) infection has been associated with intravenous (IV) immunoglobulin (Ig), and plasma donations used to prepare IV Ig are now screened to prevent transmission. Thirty-six patients from the United Kingdom received infusions from a batch of anti-HCV antibody-screened intravenous Ig (Gammagard; Baxter Healthcare Ltd., Thetford, Norfolk, England) that was associated with reports of acute hepatitis C outbreak in Europe. The aim of this study was to document the epidemiology of this outbreak.
Original languageEnglish
Pages (from-to)1120-6
Number of pages7
JournalGastroenterology
Volume110
Issue number4
DOIs
Publication statusPublished - Apr 1996

Keywords

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Child
  • Disease Outbreaks
  • Female
  • Follow-Up Studies
  • Genotype
  • Great Britain
  • Hepacivirus
  • Hepatitis C
  • Hepatitis C Antibodies
  • Humans
  • Immunoglobulins, Intravenous
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • RNA, Viral

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