Outcomes following surgical resection or surgical resection combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma

Julia Riggs, Vicki J. Adams, Joanna V. Hermer, Jane Dobson, Suzanne Murphy, Jane F. Ladlow

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE
To compare outcomes of dogs treated surgically for oral, nontonsillar, squamous
cell carcinomas (SCCs) and fibrosarcomas (FSAs) with outcomes of
dogs treated with a combination of surgery and postoperative radiotherapy;
to explore whether postoperative, hypofractionated radiotherapy improved
outcomes of dogs with incomplete excisions; and to identify prognostic
factors associated with outcome.
DESIGN
Retrospective cohort study.
ANIMALS
87 client-owned dogs that had undergone maxillectomy or mandibulectomy
for treatment of oral SCC or FSA between 2000 and 2009.
PROCEDURES
Medical records were retrospectively reviewed. Survival analysis was performed
with Kaplan-Meier and Cox regression analyses to evaluate potential
prognostic factors associated with patient outcome.
RESULTS
Median survival time (MST) for all 87 dogs was 2,049 days, but was not
reached for dogs with SCC, and was only 557 days for dogs with FSA; tumor
type was a significant predictor of survival time. Dogs undergoing postoperative
radiotherapy after incomplete excision of oral SCCs had a significantly
longer MST (2,051 days) than did dogs with incompletely excised tumors
and no radiotherapy (MST, 181 days). Postoperative radiotherapy of dogs
with incompletely excised FSAs did not appear to offer protective value
(MST, 299 days with radiotherapy and 694 days without radiotherapy).
CONCLUSIONS AND CLINICAL RELEVANCE
Wide-margin surgical excision should be considered the gold-standard treatment
for dogs with oral SCC or FSA. For dogs with oral SCCs without clean
surgical margins, survival times may be improved by providing postoperative,
hypofractionated radiotherapy.
Original languageEnglish
JournalJournal of the American Veterinary Medical Association
Volume253
DOIs
Publication statusPublished - 1 Jul 2018

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