Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom

Peter B. Sherren; Luigi Camporota; Barnaby Sanderson; Andrew Jones; Manu Shankar-Hari; Chris I.S. Meadows; Nicholas Barrett; Marlies Ostermann; Nicholas Hart

doi:10.1177/1751143720978850

Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom

Peter B. Sherren^*, Luigi Camporota, Barnaby Sanderson, Andrew Jones, Manu Shankar-Hari, Chris I.S. Meadows, Nicholas Barrett, Marlies Ostermann, Nicholas Hart

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

During the Coronavirus Disease 2019 (COVID-19) pandemic institutions have needed to develop pragmatic clinical pathways to balance the excess critical care demand and local resources. In this single-centre retrospective cohort study we describe the outcomes of COVID-19 patients admitted to Guy’s and St. Thomas’ NHS Foundation Trust (GSTT) critical care service. Patients were managed according to a local respiratory failure management pathway that was predicated on timely invasive ventilation when indicated and tailored ventilatory strategies according to pulmonary mechanics. Between 2 March and 25 May 2020 GSTT critical care service admitted 316 patients with confirmed COVID-19. Of the 201 patients admitted directly through the Emergency Department (ED) with a completed critical care outcome, 71.1% survived to critical care discharge. These favourable outcomes may serve to inform the wider debate on optimal organ support in COVID-19.

Original language	English
Pages (from-to)	233-236
Journal	Journal of the Intensive Care Society
Volume	23
Issue number	2
DOIs	https://doi.org/10.1177/1751143720978850
Publication status	Published - 14 Dec 2020

Keywords / Materials (for Non-textual outputs)

ARDS
COVID-19
respiratory failure
SARS-CoV-2
ventilation

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10.1177/1751143720978850

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Sherren, P. B., Camporota, L., Sanderson, B., Jones, A., Shankar-Hari, M., Meadows, C. I. S., Barrett, N., Ostermann, M., & Hart, N. (2020). Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom. Journal of the Intensive Care Society, 23(2), 233-236. https://doi.org/10.1177/1751143720978850

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title = "Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom",

abstract = "During the Coronavirus Disease 2019 (COVID-19) pandemic institutions have needed to develop pragmatic clinical pathways to balance the excess critical care demand and local resources. In this single-centre retrospective cohort study we describe the outcomes of COVID-19 patients admitted to Guy{\textquoteright}s and St. Thomas{\textquoteright} NHS Foundation Trust (GSTT) critical care service. Patients were managed according to a local respiratory failure management pathway that was predicated on timely invasive ventilation when indicated and tailored ventilatory strategies according to pulmonary mechanics. Between 2 March and 25 May 2020 GSTT critical care service admitted 316 patients with confirmed COVID-19. Of the 201 patients admitted directly through the Emergency Department (ED) with a completed critical care outcome, 71.1% survived to critical care discharge. These favourable outcomes may serve to inform the wider debate on optimal organ support in COVID-19.",

keywords = "ARDS, COVID-19, respiratory failure, SARS-CoV-2, ventilation",

author = "Sherren, {Peter B.} and Luigi Camporota and Barnaby Sanderson and Andrew Jones and Manu Shankar-Hari and Meadows, {Chris I.S.} and Nicholas Barrett and Marlies Ostermann and Nicholas Hart",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Shankar-Hari is supported by National Institute for Health Research Clinician Scientist Award CS-2016-16-011. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} The Intensive Care Society 2020.",

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doi = "10.1177/1751143720978850",

language = "English",

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AU - Shankar-Hari, Manu

AU - Meadows, Chris I.S.

AU - Barrett, Nicholas

AU - Ostermann, Marlies

AU - Hart, Nicholas

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Shankar-Hari is supported by National Institute for Health Research Clinician Scientist Award CS-2016-16-011. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health and Social Care. Publisher Copyright: © The Intensive Care Society 2020.

PY - 2020/12/14

Y1 - 2020/12/14

N2 - During the Coronavirus Disease 2019 (COVID-19) pandemic institutions have needed to develop pragmatic clinical pathways to balance the excess critical care demand and local resources. In this single-centre retrospective cohort study we describe the outcomes of COVID-19 patients admitted to Guy’s and St. Thomas’ NHS Foundation Trust (GSTT) critical care service. Patients were managed according to a local respiratory failure management pathway that was predicated on timely invasive ventilation when indicated and tailored ventilatory strategies according to pulmonary mechanics. Between 2 March and 25 May 2020 GSTT critical care service admitted 316 patients with confirmed COVID-19. Of the 201 patients admitted directly through the Emergency Department (ED) with a completed critical care outcome, 71.1% survived to critical care discharge. These favourable outcomes may serve to inform the wider debate on optimal organ support in COVID-19.

AB - During the Coronavirus Disease 2019 (COVID-19) pandemic institutions have needed to develop pragmatic clinical pathways to balance the excess critical care demand and local resources. In this single-centre retrospective cohort study we describe the outcomes of COVID-19 patients admitted to Guy’s and St. Thomas’ NHS Foundation Trust (GSTT) critical care service. Patients were managed according to a local respiratory failure management pathway that was predicated on timely invasive ventilation when indicated and tailored ventilatory strategies according to pulmonary mechanics. Between 2 March and 25 May 2020 GSTT critical care service admitted 316 patients with confirmed COVID-19. Of the 201 patients admitted directly through the Emergency Department (ED) with a completed critical care outcome, 71.1% survived to critical care discharge. These favourable outcomes may serve to inform the wider debate on optimal organ support in COVID-19.

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Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom

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