Ovarian cyclicity and follicular recruitment in unilaterally ovariectomized mice

R. G. Gosden, Evelyn Telfer, M. J. Faddy*, D. J. Brook

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Halving the numbers of follicles in young adult mice by unilateral ovariectomy resulted in compensatory Graafian follicle growth with a reduction by about 25% of the expected number of oestrous cycles. The impact of the operation on the numbers and dynamics of preantral follicles during the first 2 months after ovariectomy was studied using a compartmental mathematical model to analyse differential follicle counts. There were changes in growth and/or death rates at all stages of follicle development, and the patterns emerging were time-dependent. The rate of follicle survival from the pool of unilaminar stages was paradoxically reduced, but those forming two granulosa cell layers continued to develop towards Graafian size. As the frequency of follicle death declined, the numbers of healthy large preantral and antral stages in unpaired ovaries rose to approach those in pairs of age-matched control ovaries, suggesting that follicles otherwise undergoing atresia were being rescued. In the long-term, follicle dynamics after unilateral ovariectomy at young ages did not appear to compromise fecundity seriously.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalJournal of reproduction and fertility
Volume87
Issue number1
DOIs
Publication statusPublished - 1989

Keywords / Materials (for Non-textual outputs)

  • follicles
  • ovary
  • unilateral
  • ovariectomy
  • oestrous
  • cycle
  • mouse

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