Ovarian epithelial tumours: Common problems in diagnosis

Awatif Al-Nafussi

Research output: Contribution to journalArticlepeer-review


Ovarian cancer is the most lethal gynaecological malignancy, with epithelial tumours being the largest group (90%). Although most ovarian tumours create no histological diagnostic problems, a small proportion may be subject to misinterpretation resulting in serious clinical implications. The following are the most commonly encountered problems in surgical pathology practice: (1) deciding whether a malignant ovarian tumour is primary or secondary; (2) the problem of borderline epithelial tumours; (3) misinterpretation of some variants of endometrioid carcinoma; (4) realizing the existence of an admixture of epithelial patterns in a single tumour - e.g. serous plus endometrioid, endometrioid plus clear cell plus serous, etc.; and (5) distinguishing poorly differentiated carcinomas from non-epithelial undifferentiated tumours. In this review an attempt to address these problems is presented with some illustrative examples. Crown

Original languageEnglish
Pages (from-to)473-499
Number of pages27
JournalCurrent Diagnostic Pathology
Issue number6
Publication statusPublished - 1 Dec 2004


  • Cancer
  • Differential diagnosis
  • Metastatic
  • Ovary
  • Primary

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