Overcoming inhibition in the spindle checkpoint

Vincent Vanoosthuyse, Kevin G Hardwick

Research output: Contribution to journalArticlepeer-review

Abstract

Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
Original languageEnglish
Pages (from-to)2799-805
Number of pages7
JournalGenes & Development
Volume23
Issue number24
DOIs
Publication statusPublished - Dec 2009

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