Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

M  Lai; J  Seckl; M  Macleod

doi:10.1016/j.molbrainres.2004.11.008

Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

M Lai
, J Seckl
, M Macleod

Research output: Contribution to journal › Article › peer-review

Abstract

Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by M R antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury. (c) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	276-279
Number of pages	4
Journal	Molecular brain research
Volume	135
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molbrainres.2004.11.008
Publication status	Published - 27 Apr 2005

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10.1016/j.molbrainres.2004.11.008

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title = "Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells",

abstract = "Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by M R antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury. (c) 2004 Elsevier B.V. All rights reserved.",

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AU - Lai, M

AU - Seckl, J

AU - Macleod, M

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N2 - Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by M R antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury. (c) 2004 Elsevier B.V. All rights reserved.

AB - Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by M R antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury. (c) 2004 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.molbrainres.2004.11.008

DO - 10.1016/j.molbrainres.2004.11.008

M3 - Article

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VL - 135

SP - 276

EP - 279

JO - Molecular brain research

JF - Molecular brain research

IS - 1-2

ER -

Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

Abstract

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