OXA-type carbapenemases in Acinetobacter baumannii in South America

Andres Opazo, Mariana Dominguez, Helia Bello, Sebastian G. B. Amyes, Gerardo Gonzalez-Rocha*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection, occurring mostly in intensive care units. The increasing incidence of carbapenem resistance in A. baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. The most important mechanism of carbapenem resistance is the enzymatic hydrolysis mediated by carbapenemases. In A. baumannii these enzymes are usually OXA-type carbapenemases, and belong to class D according to the classification of Ambler. The OXA-type carbapenemases are divided into five subgroups, four of which correspond to acquired carbapenemases, which accounts for the distribution of genes bla(OXA) in different geographic areas. In this work we review the different types of OXA-type carbapenemases present in A. baumannii, emphasizing the current situation in South America with special mention to the findings in Chile.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalJournal of infection in developing countries
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords / Materials (for Non-textual outputs)

  • HYDROLYZING OXACILLINASE OXA-58
  • BLA(OXA-58)
  • OXA-type carbapenemases
  • Chile
  • ARGENTINA
  • South America
  • Acinetobacter baumannii
  • carbapenem-resistance
  • BETA-LACTAMASES
  • EFFLUX PUMPS
  • IMIPENEM-RESISTANCE
  • SPREAD
  • SPP.
  • EXPRESSION
  • MECHANISMS

Fingerprint

Dive into the research topics of 'OXA-type carbapenemases in Acinetobacter baumannii in South America'. Together they form a unique fingerprint.

Cite this