Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

Khalida A Lockman, James P Baren, Christopher J Pemberton, Hussam Baghdadi, Karl E Burgess, Nikolas Plevris-Papaioannou, Patricia Lee, Forbes Howie, Geoff Beckett, Anne Pryde, Alan J Jaap, Peter C Hayes, Celine Filippi, John Plevris

Research output: Contribution to journalArticlepeer-review

Abstract

There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.
Original languageEnglish
Pages (from-to)1079-92
Number of pages14
JournalLiver International
Volume32
Issue number7
DOIs
Publication statusPublished - 2012

Keywords

  • mitochondrial dysfunction
  • N-acetylcysteine
  • nonalcoholic fatty liver disease

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