Abstract
There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.
Original language | English |
---|---|
Pages (from-to) | 1079-92 |
Number of pages | 14 |
Journal | Liver International |
Volume | 32 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2012 |
Keywords / Materials (for Non-textual outputs)
- mitochondrial dysfunction
- N-acetylcysteine
- nonalcoholic fatty liver disease