Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

Khalida A Lockman; James P Baren; Christopher J Pemberton; Hussam Baghdadi; Karl E Burgess; Nikolas Plevris-Papaioannou; Patricia Lee; Forbes Howie; Geoff Beckett; Anne Pryde; Alan J Jaap; Peter C Hayes; Celine Filippi; John Plevris

doi:10.1111/j.1478-3231.2012.02775.x

Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

Khalida A Lockman, James P Baren, Christopher J Pemberton, Hussam Baghdadi, Karl E Burgess, Nikolas Plevris-Papaioannou, Patricia Lee, Forbes Howie, Geoff Beckett, Anne Pryde, Alan J Jaap, Peter C Hayes, Celine Filippi, John Plevris

Research output: Contribution to journal › Article › peer-review

Abstract

There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.

Original language	English
Pages (from-to)	1079-92
Number of pages	14
Journal	Liver International
Volume	32
Issue number	7
DOIs	https://doi.org/10.1111/j.1478-3231.2012.02775.x
Publication status	Published - 2012

Keywords / Materials (for Non-textual outputs)

mitochondrial dysfunction
N-acetylcysteine
nonalcoholic fatty liver disease

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10.1111/j.1478-3231.2012.02775.x

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Lockman, K. A., Baren, J. P., Pemberton, C. J., Baghdadi, H., Burgess, K. E., Plevris-Papaioannou, N., Lee, P., Howie, F., Beckett, G., Pryde, A., Jaap, A. J., Hayes, P. C., Filippi, C., & Plevris, J. (2012). Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis. Liver International, 32(7), 1079-92. https://doi.org/10.1111/j.1478-3231.2012.02775.x

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title = "Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis",

abstract = "There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.",

keywords = "mitochondrial dysfunction, N-acetylcysteine, nonalcoholic fatty liver disease",

author = "Lockman, {Khalida A} and Baren, {James P} and Pemberton, {Christopher J} and Hussam Baghdadi and Burgess, {Karl E} and Nikolas Plevris-Papaioannou and Patricia Lee and Forbes Howie and Geoff Beckett and Anne Pryde and Jaap, {Alan J} and Hayes, {Peter C} and Celine Filippi and John Plevris",

note = "{\textcopyright} 2012 John Wiley & Sons A/S.",

year = "2012",

doi = "10.1111/j.1478-3231.2012.02775.x",

language = "English",

volume = "32",

pages = "1079--92",

journal = "Liver International",

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Lockman, KA, Baren, JP, Pemberton, CJ, Baghdadi, H, Burgess, KE, Plevris-Papaioannou, N, Lee, P, Howie, F, Beckett, G, Pryde, A, Jaap, AJ , Hayes, PC, Filippi, C & Plevris, J 2012, 'Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis', Liver International, vol. 32, no. 7, pp. 1079-92. https://doi.org/10.1111/j.1478-3231.2012.02775.x

TY - JOUR

T1 - Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

AU - Lockman, Khalida A

AU - Baren, James P

AU - Pemberton, Christopher J

AU - Baghdadi, Hussam

AU - Burgess, Karl E

AU - Plevris-Papaioannou, Nikolas

AU - Lee, Patricia

AU - Howie, Forbes

AU - Beckett, Geoff

AU - Pryde, Anne

AU - Jaap, Alan J

AU - Hayes, Peter C

AU - Filippi, Celine

AU - Plevris, John

PY - 2012

Y1 - 2012

N2 - There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.

AB - There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the metabolism of energy substrates.

KW - mitochondrial dysfunction

KW - N-acetylcysteine

KW - nonalcoholic fatty liver disease

U2 - 10.1111/j.1478-3231.2012.02775.x

DO - 10.1111/j.1478-3231.2012.02775.x

M3 - Article

C2 - 22429485

SN - 1478-3223

VL - 32

SP - 1079

EP - 1092

JO - Liver International

JF - Liver International

IS - 7

ER -

Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

Abstract

Keywords / Materials (for Non-textual outputs)

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