Oxytocin: Control of Secretion by the Brain and Central Roles

John A Russell, Paula Brunton

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Oxytocin is a nonapeptide produced by hypothalamic neurons, some of which project to the posterior pituitary, and others have targets in brain and spinal cord. Oxytocin secretion is important in parturition and essential for lactation. Oxytocin peptide and receptor gene regulation by sex steroids is described. The oxytocin receptor and post-receptor metabotropic pathways are detailed. Neural circuits controlling oxytocin neurons, transmitters they use and patterns of oxytocin secretion generated are described. Promotion by oxytocin in the brain of behaviors and emotionality conducive to reproduction and social interaction is critically reviewed. Possible consequences of derangement of central oxytocin functions are discussed.
Original languageEnglish
Title of host publicationReference Module in Neuroscience and Biobehavioral Psychology
PublisherElsevier
Pages1-14
DOIs
Publication statusE-pub ahead of print - 31 Oct 2016

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