Oxytocin: Control of Secretion by the Brain and Central Roles

John A Russell; Paula Brunton

doi:10.1016/B978-0-12-809324-5.02246-X

Oxytocin: Control of Secretion by the Brain and Central Roles

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract / Description of output

Oxytocin is a nonapeptide produced by hypothalamic neurons, some of which project to the posterior pituitary, and others have targets in brain and spinal cord. Oxytocin secretion is important in parturition and essential for lactation. Oxytocin peptide and receptor gene regulation by sex steroids is described. The oxytocin receptor and post-receptor metabotropic pathways are detailed. Neural circuits controlling oxytocin neurons, transmitters they use and patterns of oxytocin secretion generated are described. Promotion by oxytocin in the brain of behaviors and emotionality conducive to reproduction and social interaction is critically reviewed. Possible consequences of derangement of central oxytocin functions are discussed.

Original language	English
Title of host publication	Reference Module in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier
Pages	1-14
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.02246-X
Publication status	E-pub ahead of print - 31 Oct 2016

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title = "Oxytocin: Control of Secretion by the Brain and Central Roles",

abstract = "Oxytocin is a nonapeptide produced by hypothalamic neurons, some of which project to the posterior pituitary, and others have targets in brain and spinal cord. Oxytocin secretion is important in parturition and essential for lactation. Oxytocin peptide and receptor gene regulation by sex steroids is described. The oxytocin receptor and post-receptor metabotropic pathways are detailed. Neural circuits controlling oxytocin neurons, transmitters they use and patterns of oxytocin secretion generated are described. Promotion by oxytocin in the brain of behaviors and emotionality conducive to reproduction and social interaction is critically reviewed. Possible consequences of derangement of central oxytocin functions are discussed.",

author = "Russell, {John A} and Paula Brunton",

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AB - Oxytocin is a nonapeptide produced by hypothalamic neurons, some of which project to the posterior pituitary, and others have targets in brain and spinal cord. Oxytocin secretion is important in parturition and essential for lactation. Oxytocin peptide and receptor gene regulation by sex steroids is described. The oxytocin receptor and post-receptor metabotropic pathways are detailed. Neural circuits controlling oxytocin neurons, transmitters they use and patterns of oxytocin secretion generated are described. Promotion by oxytocin in the brain of behaviors and emotionality conducive to reproduction and social interaction is critically reviewed. Possible consequences of derangement of central oxytocin functions are discussed.

U2 - 10.1016/B978-0-12-809324-5.02246-X

DO - 10.1016/B978-0-12-809324-5.02246-X

M3 - Chapter (peer-reviewed)

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BT - Reference Module in Neuroscience and Biobehavioral Psychology

PB - Elsevier

ER -

Oxytocin: Control of Secretion by the Brain and Central Roles

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