Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: Preliminary findings in autistic vs non-autistic women

Tanya L Procyshyn, Michael V Lombardo, Meng-Chuan Lai, Nazia Jassim, Bonnie Auyeung, Sarah K Crockford, Julia B Deakin, Sentil Soubramanian, Akeem Sule, David Terburg, Simon Baron-Cohen, Richard A I Bethlehem

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Oxytocin is hypothesized to promote social interactions by enhancing the salience of social stimuli. While previous neuroimaging studies have reported that oxytocin enhances amygdala activation to face stimuli in autistic men, effects in autistic women remain unclear. In this study, the influence of intranasal oxytocin on activation and functional connectivity of the basolateral amygdala - the brain's "salience detector" - while processing emotional faces vs. shapes was tested in 16 autistic and 21 non-autistic women by fMRI in a placebo-controlled, within-subjects, cross-over design. In the placebo condition, minimal activation differences were observed between autistic and non-autistic women. However, significant drug × group interactions were observed for both basolateral amygdala activation and functional connectivity. Oxytocin increased left basolateral amygdala activation among autistic women (35 voxel cluster, MNI coordinates of peak voxel= -22 -10 -28; mean change=+0.079%, t=3.159, ptukey=0.0166), but not non-autistic women (mean change =+0.003%, t=0.153, ptukey=0.999). Furthermore, oxytocin increased functional connectivity of the right basolateral amygdala with brain regions associated with socio-emotional information processing in autistic women, but not non-autistic women, attenuating group differences in the placebo condition. Taken together, these findings extend evidence of oxytocin's effects on the amygdala to specifically include autistic women and specify the subregion of the effect.
Original languageEnglish
JournalSocial Cognitive and Affective Neuroscience
Early online date7 Mar 2022
DOIs
Publication statusE-pub ahead of print - 7 Mar 2022

Keywords / Materials (for Non-textual outputs)

  • autism
  • basolateral amygdala
  • emotional face processing
  • oxytocin
  • salience

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